Our research
Understanding the molecular mechanisms that underpin pathological platelet activation and occlusive thrombi formation is essential to understand the progression of cardiovascular disease and the events, which trigger blood clot formation.
Thrombosis is a multicellular process involving a range of cell types and factors within the blood and vasculature. Therapeutic strategies that target the multi-faceted nature of thrombosis could offer a multi-factorial approach to the treatment and prevention of myocardial infarction, ischaemic stroke and cardiovascular disease.
Investigating these pathological processes in different patient populations at high risk of thrombosis will enable us to identify novel antithrombotic drug targets and develop stratified approaches to preventing heart attacks and strokes in different patient populations, enabling us to develop a personalised approach to the treatment of CVD.
The British Heart Foundation and NC3Rs fund thrombosis research at Manchester Met.
British Heart Foundation-funded projects:
- Three-year project grant - Pim kinase in the regulation of platelet function, thrombosis and haemostasis
- PhD studentship - SIRT1: a novel antithrombotic target in cardiovascular disease?
- Three-year project grant – Defining the mechanisms of normal and pathological force sensing by endothelial cell adhesion complexes
NC3Rs funded grants:
- Development of E-Sense - A flexible in vitro platform to determine cardiovascular risk
- Development and characterization of a novel endothelialized in vitro model of human atherothrombosis
- Vice-Chancellor studentship - Modulation of thrombosis and antithrombotic efficacy by endothelial dysfunction